USP25 and 28 inhibitor AZ-1 ( AZ1 )

Catalog No. M13455 CAS No. 2165322-94-9

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Product Name

USP25 and 28 inhibitor AZ-1
Note

Research use only, not for human use.
Brief Description

USP25 and 28 inhibitor AZ-1 (AZ1) is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively.
Description

USP25 and 28 inhibitor AZ-1 (AZ1) is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
Synonyms

AZ1
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

CAS Number

2165322-94-9
Formula Weight

422.22
Molecular Formula

C17H16BrF4NO2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

FC(C1=CC(COC2=CC=C(Br)C=C2CNCCO)=CC=C1F)(F)F
Chemical Name

2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethan-1-ol

1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.

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